研究兴趣
Professor
肌动蛋白动力学调控及基因组对肌动蛋白功能的影响分析.
Assistant Professor
Elucidate the structure, 内在无序蛋白和蛋白区(IDPs/IDRs)的动力学和功能及其翻译后修饰的生物学调控.
Professor
Fibrosis; Scarring; Protein degradation; ubiquitin; integrins; cytoskeleton; patient-derived model systems
Associate Professor
- 细胞外激酶信号
- 细胞外伴侣功能
- 针对泌尿系统癌症的细胞外信号网络
Professor
Molecular mechanisms of protein transport and localization in retinal neurons; mechanisms of retinal degenerative diseases
Distinguished Professor
线粒体生物学,应激信号和衰老相关的退行性疾病.
Professor
染色质的表观遗传调控, Mixed Lineage Leukemia, Structural Biology, Enzymology, Biophysical Chemistry, Rational drug design
Associate Professor
F-type ATP synthases; bioenergetics of pathogenic bacteria; enzymology; structural biology, membrane protein function.
Associate Professor
染色体DNA复制起点(位置), timing and regulation), 复制分叉完整性和检查点规则, 酵母和人类基因组的基因组不稳定性和染色体脆弱性
Associate Professor
我的研究包括研究microRNA在白血病发展中的作用.
Research Scientist
发育和疾病中的基因表达,RNA pol II调控,同源异构体基因,脯氨酸异构酶
杰出教学教授
液泡H+ atp酶(结构), function, assembly and regulation), cellular pH homeostasis, cellular stress responses, protein sorting, genomics, yeast as a model system
Professor
我的研究主要集中在确定SHIP1在免疫中的作用, obesity, 干细胞生物学和癌症. 本研究表明,SHIP1在调节造血干细胞和间充质干细胞稳态的信号通路中发挥着重要作用, (2)髓细胞终末分化, 急性骨髓移植排斥反应, (4) T细胞在小肠中的存活(5)血液病癌细胞的存活. 最近,我们开发了SHIP1和pan-SHIP1/2抑制剂,并证明它们可以在体内扩增干细胞, reverse obesity, 根除某些癌症,提高肿瘤免疫力. 我们还试图更好地了解LRBA在免疫细胞中的作用. LRBA是一种支架蛋白,通过受体信号协调细胞内囊泡运输.
Professor
视觉转导,基因表达,膜蛋白
Associate Professor
RNA聚合酶I转录(结构, assembly, regulation), nucleolar biology, 大分子结构, crosslinking, proteomics, bioinformatics, modeling, molecular genetics, biochemistry, model systems
Associate Professor
Cancer biology, cell signaling, 肌动蛋白细胞骨架在肿瘤进展中的作用, mouse models of cancer
Professor
Cancer systems biology, bioinformatics, 大数据和生存预测分析, 预测性和个性化医疗, 计算基因组和转录组生物学, non-B DNA structures, RNA:DNA hybrids, R-loops, G-quadruplexes, ncRNAs, 临床生物标志物的发现和验证
Professor
蛋白质工程,设计和折叠
Professor
- 神经和精神疾病的遗传、表观遗传和神经解剖学基础
- 正常和疾病状态下的基底神经节和小脑回路
- 神经免疫和肠道-大脑的相互作用
- 生物标记物发现的机器学习方法
- 下一代多组数据分析(基因组)测序, transcriptome, microbiome, methylome)
Professor
分子伴侣蛋白Hsp90在癌症中的作用
肾癌,膀胱癌,乳腺癌
结节性硬化综合征(TSC)
伯特-霍格-杜伯综合症(BHD)
Distinguished Professor
易引起自身免疫的基因和病毒, Genetics, Apoptosis, Endogenous Retroviruses, Transaldolase
Professor and Chair
Neurogenesis; Retinal Progenitor Cells Specification and Proliferation; Genetic Control of Stem Cell Identity and Maintenance; Disease Genes Analysis in Drosophila
Associate Professor
了解肌肉细胞如何将肌动蛋白骨架组织成有效的收缩单元, using a combination of in vitro 生物化学,以及培养肌肉细胞和遗传模型的分析 C. elegans and zebrafish.
Associate Professor
- 肌动蛋白丝聚合的调控
- 肌动蛋白-微管串扰的机制
- 肌动蛋白和微管在神经退行性疾病中的作用, 特别是肌萎缩性侧索硬化症(ALS).
- 单分子超分辨显微技术(1).e. TIRF, STED, STORM).
Professor
Ribonucleoprotein assembly and biogenesis; mitochondrial RNA import, mRNA degradation, cell cycle control
Associate Professor
Mammalian retinal stem cells formation; molecular mechanism of retinal cell fate decisions; vascular development in the CNS; using cell replacement therapy to heal the blinded eye.
Associate Professor
膜结合转运蛋白的结构和机制
Associate Professor
The molecular basis of retinal stem cell formation; regulating retinal stem/progenitor cell proliferation; using retinal stem/progenitor cells to heal the injured or degenerating retina.